WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:MAPK signaling pathway       ID:04010
C=268; O=13; E=1.73; R=7.53; rawP=2.56e-08; adjP=6.40e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000128591 NA FLNC filamin C, gamma 2318 ENSG00000128591
2  ENSG00000198909 NA MAP3K3 mitogen-activated protein kinase kinase kinase 3 4215 ENSG00000198909
3  ENSG00000176697 NA BDNF brain-derived neurotrophic factor 627 ENSG00000176697
4  ENSG00000164305 NA CASP3 caspase 3, apoptosis-related cysteine peptidase 836 ENSG00000164305
5  ENSG00000116717 NA GADD45A growth arrest and DNA-damage-inducible, alpha 1647 ENSG00000116717
6  ENSG00000184545 NA DUSP8 dual specificity phosphatase 8 1850 ENSG00000184545
7  ENSG00000112658 NA SRF serum response factor (c-fos serum response element-binding transcription factor) 6722 ENSG00000112658
8  ENSG00000158186 NA MRAS muscle RAS oncogene homolog 22808 ENSG00000158186
9  ENSG00000135341 NA MAP3K7 mitogen-activated protein kinase kinase kinase 7 6885 ENSG00000135341
10  ENSG00000092969 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
11  ENSG00000133818 NA RRAS2 related RAS viral (r-ras) oncogene homolog 2 22800 ENSG00000133818
12  ENSG00000138032 NA PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 5495 ENSG00000138032
13  ENSG00000077782 NA FGFR1 fibroblast growth factor receptor 1 2260 ENSG00000077782


Database:KEGG pathway       Name:Regulation of actin cytoskeleton       ID:04810
C=213; O=12; E=1.37; R=8.74; rawP=1.71e-08; adjP=6.40e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000101335 NA MYL9 myosin, light chain 9, regulatory 10398 ENSG00000101335
2  ENSG00000083457 NA ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 3682 ENSG00000083457
3  ENSG00000084112 NA SSH1 slingshot homolog 1 (Drosophila) 54434 ENSG00000084112
4  ENSG00000213639 NA PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 5500 ENSG00000213639
5  ENSG00000158186 NA MRAS muscle RAS oncogene homolog 22808 ENSG00000158186
6  ENSG00000154380 NA ENAH enabled homolog (Drosophila) 55740 ENSG00000154380
7  ENSG00000077522 NA ACTN2 actinin, alpha 2 88 ENSG00000077522
8  ENSG00000133818 NA RRAS2 related RAS viral (r-ras) oncogene homolog 2 22800 ENSG00000133818
9  ENSG00000101608 NA MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 10627 ENSG00000101608
10  ENSG00000165410 NA CFL2 cofilin 2 (muscle) 1073 ENSG00000165410
11  ENSG00000146426 NA TIAM2 T-cell lymphoma invasion and metastasis 2 26230 ENSG00000146426
12  ENSG00000077782 NA FGFR1 fibroblast growth factor receptor 1 2260 ENSG00000077782


Database:KEGG pathway       Name:Tight junction       ID:04530
C=132; O=8; E=0.85; R=9.40; rawP=2.49e-06; adjP=4.15e-05
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000113575 NA PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 5515 ENSG00000113575
2  ENSG00000101335 NA MYL9 myosin, light chain 9, regulatory 10398 ENSG00000101335
3  ENSG00000158186 NA MRAS muscle RAS oncogene homolog 22808 ENSG00000158186
4  ENSG00000077522 NA ACTN2 actinin, alpha 2 88 ENSG00000077522
5  ENSG00000151276 NA MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 9223 ENSG00000151276
6  ENSG00000133818 NA RRAS2 related RAS viral (r-ras) oncogene homolog 2 22800 ENSG00000133818
7  ENSG00000101608 NA MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 10627 ENSG00000101608
8  ENSG00000104695 NA PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 5516 ENSG00000104695


Database:KEGG pathway       Name:Oocyte meiosis       ID:04114
C=112; O=5; E=0.72; R=6.93; rawP=0.0008; adjP=0.0100
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000213639 NA PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 5500 ENSG00000213639
2  ENSG00000113575 NA PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 5515 ENSG00000113575
3  ENSG00000134308 NA YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 10971 ENSG00000134308
4  ENSG00000129055 NA ANAPC13 anaphase promoting complex subunit 13 25847 ENSG00000129055
5  ENSG00000104695 NA PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 5516 ENSG00000104695


Database:KEGG pathway       Name:Cell cycle       ID:04110
C=124; O=5; E=0.80; R=6.26; rawP=0.0013; adjP=0.0117
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000134308 NA YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 10971 ENSG00000134308
2  ENSG00000166483 NA WEE1 WEE1 homolog (S. pombe) 7465 ENSG00000166483
3  ENSG00000116717 NA GADD45A growth arrest and DNA-damage-inducible, alpha 1647 ENSG00000116717
4  ENSG00000129055 NA ANAPC13 anaphase promoting complex subunit 13 25847 ENSG00000129055
5  ENSG00000092969 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969


Database:KEGG pathway       Name:Neurotrophin signaling pathway       ID:04722
C=127; O=5; E=0.82; R=6.11; rawP=0.0014; adjP=0.0117
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000134308 NA YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 10971 ENSG00000134308
2  ENSG00000198909 NA MAP3K3 mitogen-activated protein kinase kinase kinase 3 4215 ENSG00000198909
3  ENSG00000176697 NA BDNF brain-derived neurotrophic factor 627 ENSG00000176697
4  ENSG00000134243 NA SORT1 sortilin 1 6272 ENSG00000134243
5  ENSG00000179295 NA PTPN11 protein tyrosine phosphatase, non-receptor type 11 5781 ENSG00000179295


Database:KEGG pathway       Name:Toxoplasmosis       ID:05145
C=132; O=5; E=0.85; R=5.88; rawP=0.0017; adjP=0.0121
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000096968 NA JAK2 Janus kinase 2 3717 ENSG00000096968
2  ENSG00000164305 NA CASP3 caspase 3, apoptosis-related cysteine peptidase 836 ENSG00000164305
3  ENSG00000135341 NA MAP3K7 mitogen-activated protein kinase kinase kinase 7 6885 ENSG00000135341
4  ENSG00000092969 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
5  ENSG00000087258 NA GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 2775 ENSG00000087258


Database:KEGG pathway       Name:Focal adhesion       ID:04510
C=200; O=6; E=1.29; R=4.65; rawP=0.0020; adjP=0.0125
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000213639 NA PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 5500 ENSG00000213639
2  ENSG00000128591 NA FLNC filamin C, gamma 2318 ENSG00000128591
3  ENSG00000101335 NA MYL9 myosin, light chain 9, regulatory 10398 ENSG00000101335
4  ENSG00000077522 NA ACTN2 actinin, alpha 2 88 ENSG00000077522
5  ENSG00000105971 NA CAV2 caveolin 2 858 ENSG00000105971
6  ENSG00000101608 NA MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 10627 ENSG00000101608


Database:KEGG pathway       Name:Amoebiasis       ID:05146
C=106; O=4; E=0.68; R=5.85; rawP=0.0050; adjP=0.0227
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000164305 NA CASP3 caspase 3, apoptosis-related cysteine peptidase 836 ENSG00000164305
2  ENSG00000077522 NA ACTN2 actinin, alpha 2 88 ENSG00000077522
3  ENSG00000092969 NA TGFB2 transforming growth factor, beta 2 7042 ENSG00000092969
4  ENSG00000075785 NA RAB7A RAB7A, member RAS oncogene family 7879 ENSG00000075785


Database:KEGG pathway       Name:Protein processing in endoplasmic reticulum       ID:04141
C=165; O=5; E=1.06; R=4.70; rawP=0.0045; adjP=0.0227
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000138674 NA SEC31A SEC31 homolog A (S. cerevisiae) 22872 ENSG00000138674
2  ENSG00000117643 NA MAN1C1 mannosidase, alpha, class 1C, member 1 57134 ENSG00000117643
3  ENSG00000087074 NA PPP1R15A protein phosphatase 1, regulatory subunit 15A 23645 ENSG00000087074
4  ENSG00000165280 NA VCP valosin containing protein 7415 ENSG00000165280
5  ENSG00000172071 NA EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 9451 ENSG00000172071




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).